Tryptophan synthase alpha chain (Escherichia coli K

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1 Names and Identifiers

1.1 Synonyms

Tryptophan synthase alpha chain EC 4.2.1.20

1.2 Other Identifiers

1.2.1 RefSeq Accession

NP_415776.1WP_000443067.1

1.2.2 UniProt ID

P0A877

1.2.3 Enzyme Commission (EC) Number

4.2.1.20

1.2.4 PRO ID

PR:P0A877

1.2.5 NCBI Proteins

1.2.6 STRING Protein ID

511145.b1260

1.2.7 BRENDA EC Number

4.2.1.20

1.2.8 IntAct Protein

P0A877

1.2.9 InterPro Protein

P0A877

2 Related Records

2.1 Same-Gene Proteins

C4ZTV3B1ITJ5A7ZZJ6B1XBK9P0A878

3 Chemicals and Bioactivities

3.1 Tested Compounds

4 BioAssays

5 Sequence

>sp|P0A877|TRPA_ECOLI Tryptophan synthase alpha chain (Run BLAST)

MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS

6 3D Structures

6.1 PDB Structures

6.2 NCBI Protein Structures

View all 4 structures

6.3 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

7 Domains

7.1 CDD Domains

tryptophan synthase, alpha subunit

7.2 InterPro Domains

Tryptophan synthase, alpha chainRibulose-phosphate binding barrelAldolase-type TIM barrelTryptophan synthase, alpha chain, active site

8 Interactions and Pathways

8.1 Interactions

8.2 Pathways

9 Biochemical Reactions

10 Literature

10.1 Consolidated References

11 Patents

12 Classification

12.1 ChEMBL Target Tree

12.2 Enzyme Classification

13 Information Sources

Filter by Source

NCBI Protein

LICENSE

NCBI Website and Data Usage Policies and Disclaimers

https://www.ncbi.nlm.nih.gov/home/about/policies/

https://www.ncbi.nlm.nih.gov/protein/P0A877

PubChem

https://pubchem.ncbi.nlm.nih.gov

BioGRID

LICENSE

The MIT License (MIT); Copyright Mike Tyers Lab

https://wiki.thebiogrid.org/doku.php/terms_and_conditions

https://thebiogrid.org/4260129

Database of Interacting Proteins (DIP)

LICENSE

All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.

https://dip.doe-mbi.ucla.edu/dip/termsofuse.html

https://dip.doe-mbi.ucla.edu/dip/DIPview.cgi?PK=35957

STRING: functional protein association networks

LICENSE

Creative Commons BY 4.0

https://string-db.org/cgi/access?footer_active_subpage=licensing

https://string-db.org/network/511145.b1260

BRENDA: Enzyme Functional Data

LICENSE

The usage of the BRENDA data is licensed under Creative Commons Attribution License CC BY 4.0.

https://www.brenda-enzymes.org/license.php

https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.20&UniProtAcc=P0A877

IntAct Molecular Interaction Database

LICENSE

Creative Commons Attribution 4.0 International (CC BY 4.0) License

https://www.ebi.ac.uk/intact/about#license_privacy

https://www.ebi.ac.uk/intact/search?query=P0A877

InterPro

LICENSE

All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.

https://www.ebi.ac.uk/interpro/about/license/

https://www.ebi.ac.uk/interpro/protein/reviewed/P0A877

NCBI Conserved Domains (CDD)

LICENSE

NCBI Website and Data Usage Policies and Disclaimers

https://www.ncbi.nlm.nih.gov/home/about/policies/

https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?SEQUENCE=P0A877

NCBI Structure

LICENSE

NCBI Website and Data Usage Policies and Disclaimers

https://www.ncbi.nlm.nih.gov/home/about/policies/

https://www.ncbi.nlm.nih.gov/structure?LinkName=protein_structure&from_uid=67473577

Protein Ontology

LICENSE

PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).

https://proconsortium.org/app/entry/PR:P0A877

UniProt

LICENSE

We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.

https://www.uniprot.org/help/license

https://www.uniprot.org/uniprot/P0A877

RCSB Protein Data Bank (RCSB PDB)

LICENSE

Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.

https://www.rcsb.org/pages/policies

https://www.rcsb.org/pdb/protein/P0A877

ChEMBL

LICENSE

Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).

http://www.ebi.ac.uk/Information/termsofuse.html

ChEMBL Protein Target Tree

https://www.ebi.ac.uk/chembl/g/#browse/targets

Swiss Institute of Bioinformatics ENZYME

LICENSE

Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).

https://enzyme.expasy.org/

Enzyme Classification

https://enzyme.expasy.org/

AlphaFold DB

LICENSE

All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.

https://alphafold.ebi.ac.uk/faq

Rhea - annotated reactions database

LICENSE

Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.

https://www.rhea-db.org/help/license-disclaimer

https://www.rhea-db.org/

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