Bioavailability and pharmacokinetics of D

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. 1983 Feb;10(1):90-4.

PMID: 6842492

Bioavailability and pharmacokinetics of D-penicillamine

W R Kukovetz et al. J Rheumatol. 1983 Feb.

Abstract

The absolute and the relative bioavailability of D-penicillamine, available from different dosage forms and products, was studied in 10 healthy volunteers. Plasma levels and urine excretion of D-penicillamine were determined up to 8 h after administration by high performance liquid chromatography after intravenous administration of 250 mg and after oral administration of 250 mg (2 products) and 150 mg (1 product) D-penicillamine. The absolute bioavailability on oral administration was 50-70%. No statistical difference was found between the relative bioavailabilities of the different dosage forms tested.

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