Inflammation and metabolic disorders

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. 2006 Dec 14;444(7121):860-7.

doi: 10.1038/nature05485.

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PMID: 17167474 DOI: 10.1038/nature05485

Review

Inflammation and metabolic disorders

Gökhan S Hotamisligil. Nature. 2006.

Abstract

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

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