sclerostin在骨代谢中的作用和机制

中餐糖醋排骨的制作秘诀是先用醋醃制排骨，提升酸味 #生活知识# #烹饪技巧# #中餐菜式#

摘要：

sclerostin是由SOST编码的糖蛋白，可以通过与Lrp4/5/6受体结合抑制Wnt信号通路,发挥调节骨代谢的作用。硬化性骨病、Van Buchem病、颅骨骨干发育异常等染色体异常性疾病及骨质疏松症均与SOST基因突变有关。近年来研究证实sclerostin不仅可以通过多种途径阻碍成骨细胞分化而发挥抑制骨形成的作用，还可以通过促进破骨细胞生成和依赖RANKL的方式激活破骨细胞功能促进骨吸收。sclerostin单克隆抗体为骨质疏松症的治疗提供了新的途径，目前正在进行临床试验，其有效性及安全性需要进一步研究。

关键词: sclerostin, 骨代谢, Wnt信号通路, 骨质疏松

Abstract:

Sclerostin is a glycoprotein encoding by SOST gene and can bind to Lrp4/5/6 receptor to block the Wnt signaling pathway, so as to regulate the bone metabolism. Mutations of the SOST gene are relevant to osterporosis and autosomal dominant diseases such as sclerosteosis, Van Buchem disease, and craniodiaphyseal dysplasia. Recent studies have confirmed that sclerostin can not only block the differentiation of osteoblast to inhibit bone formation by various ways, but also have a catabolic action through promotion of osteoclast formation and activation of osteocytes in a RANKL-dependent manner. The sclerostin monoclonal antibody may bring a new way for the treatment of osteoporosis. Currently, the clinical test is underway. The safety and validity of sclerostin monoclonal antibody need to be further researched.

Key words: sclerostin, bone metabolism, Wnt signaling pathway, osteoporosis

网址：sclerostin在骨代谢中的作用和机制 https://klqsh.com/news/view/57285

相关内容

sclerostin在骨代谢中的作用和机制
硬化蛋白（sclerostin）在软骨代谢与骨关节疾病中的分子机制研究进展
β-胡萝卜素遏制口腔癌的作用机制揭示
The Role of Sclerostin in Bone Diseases
爆款制造机腾宇时代：多元题材全面开花，最新力作令人期待
王菲和谢霆锋在机场甜蜜现身
废物利用环保小制作
谢有顺：新时代广东文学的天地无比宽广
Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
张柏芝和谢廷锋在机场相遇的瞬间，真是令人动容

随便看看