Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta

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. 2025 Sep;138(9):1264-1277.

doi: 10.1016/j.amjmed.2025.04.034. Epub 2025 May 3.

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PMID: 40324552 DOI: 10.1016/j.amjmed.2025.04.034

Meta-Analysis

Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Seung-Kwon Myung et al. Am J Med. 2025 Sep.

Abstract

Background: Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.

Methods: PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.

Results: A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.

Conclusions: There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.

Keywords: Collagen; Meta-analysis; Randomized controlled trials; Skin aging; Skin elasticity; Skin hydration; Wrinkles.

Copyright © 2025 Elsevier Inc. All rights reserved.

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