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Lithium deficiency and the onset of Alzheimer's disease.

Aron L, Ngian ZK, Qiu C, Choi J, Liang M, Drake DM, Hamplova SE, Lacey EK, Roche P, Yuan M, Hazaveh SS, Lee EA, Bennett DA, Yankner BA. Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09335-x. Online ahead of print. Nature. 2025. PMID: 40770094

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Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial.

Zhou Y, He Y, Campbell BCV, Liebeskind DS, Yuan C, Chen H, Zhang Y, Yi T, Luo Z, Zhang Z, Meng C, Cheng J, Ouyang H, Hu J, Wang F, Zhang S, Fang Q, Hu H, Zhang X, Chen Y, Zhong W, Lansberg MG, Yan S, Lou M; HOPE investigators. Zhou Y, et al. JAMA. 2025 Aug 7:e2512063. doi: 10.1001/jama.2025.12063. Online ahead of print. JAMA. 2025. PMID: 40773205

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.

Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560

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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.

Carlsson PO, Hu X, Scholz H, Ingvast S, Lundgren T, Scholz T, Eriksson O, Liss P, Yu D, Deuse T, Korsgren O, Schrepfer S. Carlsson PO, et al. N Engl J Med. 2025 Aug 4. doi: 10.1056/NEJMoa2503822. Online ahead of print. N Engl J Med. 2025. PMID: 40757665

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G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice.

Gao P, Cao M, Wang X, Zhang H, Chen X, Song Z, Zhang M, Li L, Yin C, Yuan J, Cai S, Wang Z, Cao Z, Su C, Zhang G, Komuro I, Ge J, Li L, Zou Y. Gao P, et al. Circulation. 2025 Aug 7. doi: 10.1161/CIRCULATIONAHA.125.073947. Online ahead of print. Circulation. 2025. PMID: 40772312

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NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.

Jeong J, Hausmann S, Dong H, Szczepski K, Flores NM, Garcia Gonzalez A, Shi L, Lu X, Lempiäinen J, Jakab M, Zeng L, Chasan T, Bareke E, Dong R, Carlson E, Padilla R, Husmann D, Thompson J, Shipman GA, Zahn E, Barnes CA, Khan LF, Albertorio-Sáez LM, Brill E, Kumary VUS, Marunde MR, Maryanski DN, Szany CC, Venters BJ, Windham CL, Nowakowski ME, Czaban I, Jaremko M, Keogh MC, Le K, Soth MJ, Garcia BA, Jaremko Ł, Majewski J, Mazur PK, Gozani O. Jeong J, et al. Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09299-y. Online ahead of print. Nature. 2025. PMID: 40770093

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From complexity to consensus: A roadmap for neutrophil classification.

Ng LG, Ballesteros I, Cassatella MA, Egeblad M, Fridlender ZG, Gabrilovich D, Gao Q, Granot Z, Grieshaber-Bouyer R, Grimes HL, Hedrick CC, Hidalgo A, Kaplan MJ, Kubes P, Ling GS, Lu L, Luo HR, Mayadas TN, Moutsopoulos NM, Ng M, Nigrovic PA, Ostuni R, Pittet MJ, Quail DF, Silvestre-Roig C, Soehnlein O, Udalova IA, Xue R, Zhang N, Kwok I. Ng LG, et al. Immunity. 2025 Jul 29:S1074-7613(25)00320-6. doi: 10.1016/j.immuni.2025.07.011. Online ahead of print. Immunity. 2025. PMID: 40763729 Review.